BIRMINGHAM, AL (REIT Media) March 14, 2008 - Medical Properties Trust, Inc. (the "Company") (NYSE:MPW) announced today that it plans to make a public offering of approximately 11 million shares of its common stock. The Company expects to grant the underwriters an option to purchase up to approximately 1.65 million additional shares of common stock to cover over-allotments, if any. UBS Investment Bank will serve as sole bookrunner for the offering, with KeyBanc Capital Markets and RBC Capital Markets acting as co-lead managers and Deutsche Bank Securities, JPMorgan and Raymond James Bank acting as co-managers.

The Company intends to use the net proceeds from the offering to fund a portion of the purchase price of its acquisition of a portfolio of up to 21 healthcare facilities across 15 states from HCP, Inc. for an aggregate purchase price of approximately $371 million. The portfolio consists of seven acute care hospitals, three long-term acute care hospitals, five inpatient rehabilitation hospitals, as well as six wellness centers. Subject to customary closing conditions, the Company expects to complete the acquisition in stages beginning March 28, 2008 through the end of the second quarter of 2008.

The Company intends to fund the remainder of the purchase price of the acquisition of the HCP properties with the net proceeds the Company receives from its previously announced purchase and sale transactions with Vibra Healthcare, LLC and a combination of debt transactions, including sales of debt securities and borrowings under its existing credit facilities. The Company has also secured commitments from a syndicate of lenders for a senior secured interim loan facility, which is expected to provide up to $300 million of any unfunded balance of the purchase price.

The offering of the shares will be made under the Company's effective shelf registration statement filed with the Securities and Exchange Commission ("SEC"). The Company intends to file a prospectus supplement with the SEC for the common stock offering to which this communication relates. When available, the prospectus supplement and accompanying base prospectus may be obtained from UBS Securities LLC, Prospectus Dept., 299 Park Avenue, New York, NY 10171 or by visiting the EDGAR database on the SEC's web site at www.sec.gov.

This press release does not constitute an offer to sell or the solicitation of an offer to buy any shares of the Company’s common stock, nor shall there be any sale of these securities in any jurisdiction in which such an offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. The offering may be made only by means of a prospectus and a related prospectus supplement, which have or will be filed with the SEC.

About Medical Properties Trust, Inc.

Medical Properties Trust, Inc. is a Birmingham, Alabama, based self-advised real estate investment trust formed to capitalize on the changing trends in healthcare delivery by acquiring and developing net-leased healthcare facilities. These facilities include regional and community hospitals, rehabilitation hospitals, long-term acute care hospitals, women’s and children’s hospitals and other specialized single-discipline and ancillary facilities.

The statements in this press release that are forward looking are based on current expectations and actual results or future events may differ materially. Words such as "expects," "believes," "anticipates," "intends," "will," "should' and variations of such words and similar expressions are intended to identify such forward-looking statements. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the actual results of the Company or future events to differ materially from those expressed in or underlying such forward-looking statements, including without limitation: the Company’s ability to consummate this offering and the use of the proceeds therefrom; the Company’s ability to consummate the HCP acquisition and other acquisitions; national and economic, business, real estate and other market conditions; the competitive environment in which the Company operates; the execution of the Company's business plan; financing risks; the Company's ability to attain and maintain its status as a REIT for federal income tax purposes; acquisition and development risks; potential environmental and other liabilities; and other factors affecting the real estate industry generally or healthcare real estate in particular. For further discussion of the facts that could affect outcomes, please refer to the "Risk factors" section of the Company's Form 10-K for the year ended December 31, 2007. Except as otherwise required by the federal securities laws, the Company undertakes no obligation to update the information in this press release.

Medical Properties Trust
Charles Lambert, Finance Director, 205-397-8897
clambert@medicalpropertiestrust.com